Welcome to this free breakfast seminar at our office in Näsby Park, Täby.
This seminar will provide out overview of the challenges and limitations, but also the opportunities associated with the analysis of observational data and registry cohorts, particularly with regards to the study of long-term, real-world outcomes and as a means of supplementing the existing evidence base from primary clinical trial evidence.
It will provide an overview of some of the more notable registries and cover examples of how these are currently being used to corroborate and extend observations from clinical trials around the efficacy and safety of medical interventions, focusing on Multiple Sclerosis as an example. The session will also introduce a number of possible strategies for both diagnosing and managing the various biases and shortcomings associated with the analysis of observational cohorts including propensity score adjustment and marginal structural modelling.
Speaker : Tim Spelman, PhD - Senior Research Analyst
Dr Tim Spelman is a biostatistician of 16 years’ experience having worked with a variety of national and international research organisations including the Australian Bureau of Statistics, Melbourne Brain Centre, the Burnet Institute, Monash University’s Department of Epidemiology and Preventive Medicine, the Victorian Infectious Diseases Service, the Peter Doherty Institute for Infection and Immunology, the Department of Health the United Nations Programme on HIV/AIDS, Flinders University and Deakin University among others. He has over 135 publications in infectious diseases, immunology, multiple sclerosis, neurology, population health, epidemiology and virology. He is currently senior advising statistician to the Lancet and senior advising statistician to the Economics Sub-Committee of the Pharmaceutical Benefits Advisory Committee.
He is currently a member of the editorial board of the Journal of the International AIDS Society and the current guest Lead Editor for the Biomed International Research Journal. He is also currently a member of the international Tysabri Observation Programme steering committee and a member of the Data Management Sub-Committee for the Big MS Data Network International Collaborative of Multiple Sclerosis data registries. He is currently a member of the Data and Safety Monitoring Committee (DSMC) of the NICE-GUT randomised clinical trial of nitazoxanide for treating Aboriginal children hospitalised for gastroenteritis in the Northern Territory as well as working previously as a clinical trial statistician. He has presented research at many international conferences and workshops and run statistical training courses for researchers and clinicians in Australia, Europe, the United States, South-East Asia and Southern Africa and has collaborated extensively with research groups globally including the UN, WHO, MSF, the Karolinska Institute, Oxford and Harvard. He has also extensive clinical experience, and currently practices as a General Practitioner. He also has extensive management experience, supervising both junior statisticians and epidemiologists in addition to trainee clinicians.
Time:
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7:45-8:15 : Breakfast is served
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8:15-9:00 : Seminar
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9:00-9:15 : Q&A